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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE IX.A.4. Evidence of the effectiveness of pollen and occupational allergen avoidance and environmental controls Study Year LOE Study design Study groups Clinical endpoint Conclusion Comert et al. 1161 2016 1b RCT SAR to grass pollen (n = 70): 1 Wrap-around eyeglasses plus standard medical care; 2 Standard medical care alone Nasal and conjunctival symptom scores, rescue medication use, RQLQ Significant improvement of ocular/nasal symptoms and RQLQ in wrap-around eyeglass group. Kenney et al. 1163 2015 1b Randomized double blind, placebo controlled crossover Adults with SAR to grass pollen (n = 65): 1 Nasal membrane filter; 2 Placebo filter In-season exposure: TNSS, individual symptoms Daily sum TNSS and maximal TNSS were significant. Individual symptoms (sneezing, watery eyes, rhinorrhea) were also significantly decreased compared to placebo. Kenney et al. 1162 2014 1b Randomized double blind, placebo controlled crossover Adults with SAR to grass pollen (n = 24): 1 Nasal membrane filter; 2 Placebo filter Following ACC exposure: nasal symptom scores, conjunctival symptom scores, throat irritation, intranasal volume, oral FeNO Primary endpoint, TNSS, was not significant. Some secondary endpoints were positive. In the absence of natural allergen exposure, the conclusions of this trial are limited. Castano et al. 1165 2013 2b Cohort, prospective, open trial Occupational allergy (n = 20) Nasal symptoms, disease specific QOL, nasal patency, nasal inflammation, olfactory function EC in occupational allergy patients results in improved QOL, rhinitis-associated symptoms, and general well-being.

ACC = allergen challenge chamber; FeNO = fraction of exhaled nitric oxide; LOE = level of evidence; QOL = quality of life; RCT = randomized controlled trial; RQLQ = Rhinoconjunctivitis Quality of Life Questionnaire; SAR = seasonal allergic rhinitis.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.