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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE IX.B.1.b.

Evidence for the role of oral H 2 antihistamines in the management of allergic rhinitis Study Year LOE Study design Study groups Clinical endpoint Conclusion Taylor-Clark et al. 1194 2005 1b RCT Histamine challenge with premedication: 1 PO cetirizine; 2 PO ranitidine; 3 PO cetirizine + ranitidine; 4 Placebo Nasal airway resistance Cetirizine alone and ranitidine alone improve nasal resistance. Cetirizine plus ranitidine improves nasal resistance more than either alone.

No difference in symptoms or flowmetry with cimetidine. No additive effect of cimetidine with terfenadine.

Combination of cetirizine + cimetidine showed improved nasal airway resistance and nasal airflow over cetirizine alone.

Ranitidine improved nasal resistance more than cetirizine. Cetirizine decreased total protein and albumin more than ranitidine.

Reduced symptoms and medication scores in cimetidine plus chlorpheniramine group.

No difference in subjective scores. Increased secretion and sneeze count, no difference in nasal resistance.

Laser Doppler flowmeter, allergic symptoms

Symptoms (itching, sneezing, rhinorrhea, congestion), sneeze count, nasal airway resistance

Nasal lavage fluid protein concentration, nasal airway resistance

Symptoms (rhinorrhea, sneezing, nasal congestion, nasal pruritus,

eye discomfort), medication usage beyond study therapy

Subjective symptoms (congestion, itch, drainage, sneeze), nasal

resistance, nasal secretion weight

Juliusson & Bende 1196 1996 1b RCT Allergy challenge with premedication: 1 PO terfenadine; 2 PO cimetidine;

3 PO terfenadine + cimetidine; 4 Placebo

Wang et al. 1195 1996 1b RCT Allergy challenge with premedication: 1 PO cetirizine; 2 PO cetirizine + cimetidine

Wood-Baker et al. 1193 1996 1b RCT Allergy challenge with premedication: 1 PO cetirizine; 2 PO ranitidine

Carpenter et al. 1198 1983 1b RCT During allergy season medicated with: 1 PO chlorpheniramine;

2 PO chlorpheniramine + cimetidine

Brooks et al. 1197 1982 1b RCT Allergy challenge with premedication: 1 PO cimetidine; 2 Placebo

H 2 = histamine receptor H 2 ; LOE = level of evidence; PO = per os (medication taken orally); RCT = randomized controlled trial.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.