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73

ICAR SINONASAL TUMORS

TABLE IX.1 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

1984 4 a

1. Regional and/or distant metastasis: 33% in carcinomas, 37% in noncarcinomas 2. CT is useful to detect RPLN and cervical LN metastasis

1. Incidence of cervical LN

Weber and

Retrospective cohort

Patients with

Stanton 207

malignant paranasal sinus tumors ( n = 200, 144 carcinoma, 56 noncarcinoma)

and/or distant metastasis criteria in workupof cervical LN metastasis

2. Imaging

Ferrari et al. 231

2021

5

Review/expert opinion

Sinonasal SCC

N/A

PET/CT should be performed in advanced head and neck SCC to assess the primary site, regional metastasis, and distant metastasis 1. Clinical exam, cervical MRI and CT scan, and PET should be used to assess cervical lymphadenopathy 2. PET should be used to assess distant metastasis 3. Chest and abdominal CT and/or hepatic ultrasound should be done when specifically investigating lung and liver metastasis 1. CT, MRI, and PET/CT: essential for staging of NUT midline carcinoma 2. Occasional involvement of cervical LN, nonnecrotic 3. Distant metastasis: bone most common 1. CT and MRI to assess cervical adenopathy 2. PET and CT chest to assess distant metastasis 1. Neck palpation should be performed on physical exam to look for enlarged cervical adenopathy 2. Neck US for sinonasal tumors with the high-risk features 3. FNAC for cervical adenopathy 1. Use MRI to assess invasion of orbital contents, dura, brain, and cavernous sinus 2. Use PET–CT to: - assess for distant metastasis in primary tumors with aggressive histopathology - rule out a primary tumor elsewhere in the body if a sinonasal tumor is suspected to be a metastasis

Dumont et al. 214 2020 5

Review/expert opinion

ONB

N/A

Virarkar et al. 219 2020 5

Review/expert opinion

Imaging in NUT

N/A

midline carcinoma

Abdelmeguid et al. 210

2019 5

Review/expert opinion

SNUC

N/A

Bossi et al. 199

2016 5

Review/expert opinion

SNM

N/A

Lundet al. 68

Nose and paranasal sinus tumors

N/A

2016 5

Review/expert opin

ion/guidelines

(Continues)

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