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KUANetal.

TABLE XIV.1 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

At 2 years, there were no significant differences in LRC, PFS, or OS between those undergoing orbital preservation

1. 2-year LRC 2. 2-year PFS 3. 2-year OS

Amsbaugh et al. 501

2016 4

Retrospective case series

SNM at a single

institution treated with orbital preservation ( n = 14) versus exenteration ( n = 6)

Askoxylakis et al. 502

2016 4

Retrospective case series

SNM at a single

1. 5-year LC 2. 5-year PFS 3. 5-year OS

1. LC51% 2. PFS47% 3. OS54% 1. LC73% 2. Tox 18%

institution ( n = 122)

Burt et al. 503

2016 4

Retrospective case series Retrospective case series

SNM at a single

1. LC 2. G3Tox

institution ( n = 11)

Suhet al. 504

2016 4

SNM at a single

1. 3-year LRC IMRT 2. 3-year LRC 3DCRT 1. 5-year LRC 2. 5-year OS

1. LRC IMRT 89% 2. LRC 3DCRT 60%

institution ( n = 54; IMRT n = 19, 3DCRT n = 35) institution (IMRT n = 44, conventional n = 63)

Yinet al. 505

1. LRC73% 2. OS65%

2016 4

Retrospective case series

ONB at a single

DuruBirgi et al. 506

2015 4

Retrospective case series

SNM at a single

1. 2-year LC 2. 2-year PFS 3. 2-year OS

1. LC81% 2. PFS71% 3. OS80%

institution ( n = 43)

Batth et al. 507

2013 4

Retrospective case series

SNM at a single

Toxicity

The incidence of acute and late grade 3 + toxicity was 23% and 19%, and volumes receiving ≥ 20 Gy was the most significant predictor of late toxicity

institution ( n = 40)

Fried et al. 508

2013 4

Retrospective case series

SNM at a single

1. 3-year LC 2. 3-year OS

1. LC64% 2. OS68% 3. SNM failed marginally or

institution (IMRT n = 41, 3DCRT n = 38)

out-of-field in 53% (8/15) of LR and 31% (8/26) of all local failures 1. LRC63% 2. OS69% 3. Level Ib and level IIa were the most common sites of cervical nodal recurrence 4. None of the 11 patients who received ENI developed failure in theneck 1. PFS 65%/49% 2. OS 86%/56% 3. Tumor histology appeared to be the best way of predicting the prognosis and selecting patients for adjuvant RT 1. Eight local recurrences 2. 11 disease free at the end of follow-up

Guanet al. 509

1. 3-year LRC 2. 3-year OS

2013 4

Retrospective case series

SNM at a single

institution (IMRT n = 43, 3DCRT n = 16)

Kaur et al. 510

2013 4

Retrospective case series

ONB at a single

1. 5-year PFS low/high grade 2. 5-year OS low/high grade

institution (IMRT n = 6, EBRT n = 5)

Rajapurkar et al. 511

1. LR 2. DFS

2013 4

Retrospective case series

SNM at a single

institution (IMRT n = 7, 3DCRT n = 7)

(Continues)