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139

ICAR SINONASAL TUMORS

TABLE XVI.2 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

Cheung et al. 655

1. Severe dysplasia and p53 strongly associated with malignant transformation 2. HPV positivity was strongly associated with exophytic papilloma and carcinomas 3. Evidence of p53 and dysplasia warrant aggressive surgical treatment and close follow-up Inverse relationship between HPV and p53 overexpression and association with sinonasal carcinomas

1. Morphology of IPand expression of p53andp16 2. Association between

2010 3

Retrospective cohort

56 patients with

sinonasal IP, eight patients with sinonasal exophytic papilloma, and three patients with sinonasal oncocytic papilloma carcinoma ( n = 31) versus exophytic papilloma associated with carcinoma ( n = 5) associated sinonasal carcinomas including IP ( n = 24) and oncocytic ( n = 5)

malignant transforma tion and HPV infection

Buchwald et al. 654

2001 3

Retrospective cohort

IP associated with

1. Determine

the presence ofHPVDNA

2. Assess p53 overexpres sion

Brown et al. 660

EGFR (21/29, 72.4%) or KRAS mutations (5/29, 17.2%) were present in most tumors

Characterize the molecular landscape of a large cohort of

2021

4

Case–control

Sinonasal papilloma

sinonasal papilloma associated sinonasal carcinomas

Nishikawa et al. 661

2021

4

Case–control

85 patients with SNSCC

Prognosis of EGFR

1. EGFR mutations detected in 24 out of 85 (28%) patients 2. HPV DNA was detected in seven out of 85 (8%) patients 3. Patients with EGFR mutated SNSCC had worse OS than those with EGFR wild type 1. Recurrence rates in IP 34.09% (15/44) with a mean time of recurrence of 24.6 months 2. Malignant transformation occurred in six out of 44 (13.64%) patients with IP

mutation and HPV status in SNSCC

Sbrana et al. 644

1. Rateof

2021

4

Case–control

Sinonasal papilloma including IP ( n = 49), exophytic papilloma ( n = 6), and oncocytic papilloma ( n = 6)

recurrence in patients with IP malignant transforma tion in patients with an IP between HPV and sinonasal papilloma between HPV and sinonasal SCC

2. Rateof

Beigh et al. 754

2018 4

Case–control

102 patients with nonneoplastic

1. Association

Low-risk HPV-6 and HPV-11 were associated with sinonasal papilloma, and high-risk subtypes HPV-16 and HPV-18 were associated with SCC

sinonasal lesions versus 94 patients with neoplastic sinonasal lesions

2. Association

(Continues)