xRead - Nasal Obstruction (September 2024) Full Articles

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567

Orlandi et al.

SNOT-22 and RSDI scores Low SNOT-22 patients ( < 20) were less likely to achieve MCID compared to high-SNOT ( > = 20) (43% vs 82%; p < 0.001). SNOT-22 and RSDI scores up to 18 months post-enrollment

(Continues)

Elderly patients least likely to achieve a MCID in total SNOT-22 score compared to younger patients (66% reached MCID, p = 0.16). Similar trends for each SNOT-22 domain.

50 CRS patients Change in SNOT-22 SNOT-22 > 30hada > 90% changes of achieving MCID.

Odds of achieving MCID was greater with surgery compared to medical therapy in 3 of the 5 patient clusters. 2 of the 5 clusters showed no difference.

Factors associated with achieving MCID included pre-operative SNOT-22 score, age and missed productivity.

CRSwNP greater improvement than CRSsNP. MCID MCID values for the rhinologic, extra-nasal rhinologic, ear/facial, psychological, and sleep domain scores were: 3.8, 2.4, 3.2, 3.9, and 2.9, respectively.

Improvement in SNOT-22 scores alone does not correlate with health utility as captured bySF-6D.

Clinically significant improvement in symptoms at 6 months post-op typically

have sustained improvement long term (at least 10 years follow up).

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Smith 189 2019 3 Observational cohort study

RDSI, CSS, SF-6D

Revision surgery rate Patients satisfaction rate

59 CRS pts s/p ESS QoL outcomes:

prospective cohort 403CRSpts SNOT-22 change SF-8 scores

Health utility values

2 cohorts: Low-SNOT < 20vshigh SNOT22 >= 20 points

276 patients CRSwNP andCRSsNP post-ESS

refractory CRS

patients (medical & surgical tx), 5

clusters based on

total SNOT-22, age, andmissed productivity

690 medically

774 CRS patients

Yancey 1942 2019 3 Retrospective analysis of

observational cohort

observational cohort

observational

cohort study

observational cohort

Singla 1945 2018 3 Prospective

Levy 1951 2017 3 Prospective

Chowdhury 1935 2017 3 Prospective

Soler 1939 2016 3 Prospective

TABLE XII-11 (Continued)