xRead - Olfactory Disorders (September 2023)

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412

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Devanand et al 611

UPSIT R

2010 3

Cohort

31MCI that

At baseline, MCI converters to AD had lower UPSIT R scores than nonconverters whose scores did not differ from HCs SS-ID scores were lower in MCI, mild AD, and mild DLB than HCs Using logistic regression, the smell ID score predicted diagnosis of DLB rather than mild AD independent of age, sex, and cognitive function AD exhibited reduced threshold, discrimination, and ID scores ID scores correlated with FTG clusters in right superior parietal lobule, fusiform gyrus, inferior frontal gyrus, and precuneus Discrimination scores correlated with a single cluster in the left postcentral cortex Threshold scores correlated with right thalamus and cerebellum clusters At 18-month follow-up, 9 (31%) converted to AD and had lower UPSIT R , but not PEA threshold, poorer in AD Odor quality ratings disrupted in AD, a phenomenon suggested to be caused by functional test scores than nonconverters

converted to AD

MCI 96

nonconverters

59HCs

Williams et al 612

2009 4

Case

27mildAD 21mildDLB 21mildMCI 47HCs

SS-ID (16 odors)

control

Forster et al 613

SS-TDI FDGuptake

2010 4

Case

6 incipient AD 18mildAD 28 matched HCs

control

Fusetti et al 614

2010 3

Cohort

30AD 29aMCI

SS-TDI

Li et al 615

2010 4

Case

10AD 10 matched HCs

UPSIT R SS-T(PEA) Suprathreshold ratings of odor affective valence, intensity, familiarity fMRI cross adaptation paradigm

control

disruption of circuits within the posterior piriform cortex

(Continues)