xRead - Olfactory Disorders (September 2023)

20426984, 2022, 4, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22929, Wiley Online Library on [04/09/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

413

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Razani et al 616

Multidimensional scaling spatial odor maps of AD exhibited disorganized groupings relative to those of HCs This was not true of color maps Label matching and ADscores < MCI scores < HCs on all smell test components save no T difference between AD andMCI AD had lower scores than MCI ID, discrimination, and threshold all affected AD had less function than HCs BOLD signals correlated withUPSIT R in the AD and aMCI performed more poorly than HCs AD and aMCI did not differ No left/right nostril differences Majority of patients fell below normal Patients generally unaware ofOD Combined AD and VD group had larger just noticeable differences thanHCs AD only had largest difference from HCs AD associated with lower test scores than HCs Severe AD had lower scores than mild AD AD exhibited decline in test scores relative to other groups Elderly HCs exhibited lower scores than young HCs Cognitive measures correlated with test scores in the AD and elderly HCs (Continues) attribute sorting deficits suggested semantic OM is compromised primary olfactory cortex, hippocampus, and insula

2010 4

Case

12AD 12HCs

Similarity

control

judgments of odors and colors subjected to multidimen sional scaling

Steinbach et al 617

2010 4

Case

30AD 29MCI 29HCs

SS-TDI

control

Wanget al 618

12AD 13HCs

UPSIT R

2010 4

Case

control

fMRI

Bahar-Fuchs et al 619

2011 4

Case

25AD 25MCI 22HCs

6 items from UPSIT R Unirhinal testing Subjective perception

control

Hidalgo et al 620

Just noticeable

2011 4

Case

11AD 4VD 15 age- and

difference tool using standard and different butanol concentrations

control

sex-matched HCs

Jimboet al 621

2011 4

Case

100AD 17 age-matched HCs 30AD 30 young HCs 30 elderly HCs

OSIT-J

control

Makowska et al 622

PST

2011 4

Case

control