xRead - Olfactory Disorders (September 2023)

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411

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

B-SIT

Both AD and FTD had lower scores than the HCs and did not differ significantly from one another AD had lower scores than MCI Both had lower scores than HCs Subtypes of MCI did not differ Only modest difference between MCI and HCs Lower scores in AD than in HCs MCI scored below HCs on both odor and BNT, but Odor ID scores differed between aMCI multiple domain patients and the HCs Other differences not significant Moderate correlations between UPSIT R scores and age, subjective smell loss, and MMSE scores Annual clinical evaluations were made and brains were autopsied at death in34 B-SIT scores were associated with more cognitive impairment and with higher level of AD pathology, even after controlling for ApoE ε 4 and premortem level of episodic memory function Test scores: no MCI > naMCI > aMCI UPSIT R scores correlated with SRT immediate recall, delayed recall, category fluency, and BNT impairment odor less impaired than BNT

McLaughlin and Westervelt 604

2008 4

Case

14AD 14FTD 14HCs

control

Westervelt et al 605

2008 4

Case

44AD 83MCI 21HCs

B-SIT

control

Jungwirth et al 606

2009 4

Case

88AD 384HCs 72MCI 486HCs

3-PST

control

Laakso et al 607

2009 4

Case

Spontaneous and cued odor ID and delayed recall BNT

control

Lehrner et al 608

UPSIT R

2009 4

Case

19MCI 11 single domain aMCI 19 multiple domain aMCI 21 single domain naMCI 13 multiple

control

domain naMCI

40HCs

Wilson et al 609

2009 3

Cohort

471 cognitively normal older peopleat baseline

B-SIT Cognitive measures Autopsyof

pathologies

Devanand et al 610

UPSIT R Cognitive

2010 4

Case

170aMCI 120naMCI 802noMCI

control

measures

(Continues)