xRead - Olfactory Disorders (September 2023)

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415

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

UPSIT R baseline and 3-month retest scores

57mild to

AD had lower baseline scores than HCs MMSE scores related to baseline UPSIT R scores but not to change over time No AD-related systematic left/right differences in test scores, in contradiction to the study by Stamps et al 627 performed worse than HCs on both tests Hippocampal volume down in those with most OD AD and aMCI groups hippocampal volume loss showed same sensitivity to conversion (92.3%), but SS-TDI had a higher sensitivity (75% vs 60%) 159 (10%) converted to dementia Conversion predicted by demographic variables, MMSE, and olfactory assessments, including self-reports and olfactory test scores, with the olfactory measures being additive Lower baseline UPSIT R scores associated with transition to AD dementia 101 (13%) participants transitioned to AD dementia AD had lower scores in both olfactory tests than age-matched controls Scores on both tests were lower in the older HCs than in the younger age groups Age correlated with test scores in the non-AD groups At follow-up, 5 (28%) converted to AD Both SS-TDI score and

Velayudhan et al 628

2013 3

Case

moderate AD

control and cohort

24elderly

Dotyet al 629

2014 4

Case

20 AD tested on left and right with UPSIT R ; 15withPBT

UPSIT R PBT

control

Kjelvik et al 630

B-SIT SS-ID

2014 4

Case

6earlyAD 12aMCI 30HCs

control

Margliano et al 631

2014 3

Cohort

18 aMCI cohort followed up at 12months

SS-TDI at baseline MRI volume of hippocampus

Stanciu 632

SOIT SS-T Self-ratings of smell dysfunction

2014 3

Cohort

1529 community members with normal cognition at baseline followed over a 10-year period 757 community members without dementia followed up at 2 years and 4 years 12 patients with AD aged 62 to 85 years 40 HCs aged 20 to43years 35 HCs aged 45 to69years 38 HCs aged 70 to89years

Devanand et al 633

2015 3

Cohort

UPSIT R

Hori et al 634

OSIT-J Odor judgement test (eg, good/bad; safe/harmful)

2015 4

Case

control

(Continues)