xRead - Olfactory Disorders (September 2023)

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429

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions Peripapillary retinal nerve fiber layer thickness correlated with ID and discrimination but not threshold decreased gray matter in the anterior cingulum as well as temporal and frontal brain regions of MS relative to controls Relationship noted between SS-D + SS-I odor scores and gray matter decreases After a median follow-up of 121 months, those with impaired B-SIT at baseline had greater change per month during follow-up on severity scales and higher hazard of death The authors suggest that a brief odor ID test can be a marker of degeneration in MS MS scored lower than HCs onUPSIT R Those with higher scores reported better mental and physical QOL and performed better on the BICAMS and Actual Reality tasks The authors suggest that olfaction may be a clinical marker for MS disability Lower olfactory scores in patients with relapsing-remitting MS than HCs and correlated with 3rd ventricle width The authors suggest that OI impairment is related to cognitive dysfunction and central brain atrophy (Continues) in the olfactory gyrus, anterior cingulate, and temporal regions Statistical parameter matching found

Bstehet al 687

2020 4

Case

37MS 18HCs

SS-TDI MRI measures

control

Da Silva et al 688

2020 3

Cohort

149

B-SIT MS severity scales

Goverover et al 689

2020 4

Case

23MS 15HCs

UPSIT R Cognitive

control

measures

Okadaet al 690

OSIT-J Cognitive

2020 4

Case

40 relapsing

control

remitting MS

measures

40HCs