xRead - Olfactory Disorders (September 2023)

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431

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point UPSIT R PEA threshold

Topic

Study

Year LOE

Conclusions

Dotyet al 697

81PD 81 matched HCs

1988 3

Case

BothUPSIT R (n = 81) and threshold values (n = 38) compromised inPD No evidence of longitudinal changes in test scores over 5- to 39-month intervals Olfactory test scores independent of a range of demographic, cognitive, and motor variables 72% of PD unaware of their deficit until being tested Comparison of PD scores to Significant loss on both tests in AD and PD but not in MS Severe impairment on match-to-sample test PD test scores lower than all other groups those of matched AD found no differences component analysis on cognitive, motor, and olfactory test scores of PD revealed 6 components: cognitive/memory, gross motor, oral motor, fine motor, olfactory, and tremor These findings and those from multiple regression and canonical correlations suggest the OD of PD is independent of cognitive, perceptual-motor, and memory manifestations of the disease PD exhibited OD on both types of tests relative to HCs recognition thresholds elevated in PD Auditory acuity normal Performed principal

control and cohort

Kesslak et al 553

1988 4

Case

18AD 14PD 14MS 18HCs

UPSIT R Match-to-sample taskusing uncommon odors

control

Dotyet al 698

1989 3

Cross

58PD

UPSIT R

sectional

Bostantjopoul et al 699

1991 4

Case

44PD 30HCs

Amyl acetate threshold Odor naming test

control

Murofushi et al 700

1991 4

Case

18PD 10HCs

T&T olfactometer Both detection and

control

(Continues)