xRead - Olfactory Disorders (September 2023)

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432

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point Short-term OM and IDtest

Topic

Study

Year LOE

Conclusions

Zuccoet al 701

1991 4

Case

8PD 16 elderly HCs

PD were found more efficient in naming than in matching odors, whereas the opposite occurred in the elderly HCs Unilateral testing found all PD to have bilateral dysfunction; asymmetries were not lateralized and unrelated to side of major motor dysfunction, and did not differ from those ofHCs No influence of PD-related drugs on olfactory test scores No associations between test scores and degree of rigidity, bradykinesia, or gait disturbances PD, but not MPTP PD, scores lower than HCs on both tests Finding suggests that MPTP-induced parkinsonism, unlike idiopathic PD, is not accompanied by major changes in smell function misdiagnosed as PD PD, but not PSP, had major smell loss relative to HCs In both types of patients, no relationship between olfactory test scores and measures of motor symptom severity, disease stage, and medication use Confirmed significant decline in odor ID ability inPD UPSIT R item analyses suggested that 2 odorants, pizza and wintergreen, distinguished between with PD and HCs, with 66% and 47% differences from controls, respectively PSP is commonly

control

Dotyet al 702

1992 4

Case

20 unmediated PD 20 medicated PD 20HCs

UPSIT R

control

Dotyet al 703

UPSIT R PEA threshold

1992 4

Case

6MPTP

control

parkinsonism 12 matched PD 10 matched HCs

Dotyet al 704

1993 4

Case

21PD 21PSP 21 matched HCs

UPSIT R PEA threshold

control

Hawkes and

1993 4

Case

96PD 96HCs

UPSIT R

Shephard 705

control

(Continues)