xRead - Olfactory Disorders (September 2023)

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433

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Sternet al 706

UPSIT R

1994 4

Case

9 young-onset PD 109 older-onset PD 80 benign PD 29 malignant PD 40 tremor predominant PD 20postual instability gait disorder PD

Smell ability was compared among subtypes of PD Subtle differences occurred between benign and malignant, as well as tremor-predominant vs postural instability-gait disorder–predominant subtypes Established optimal UPSIT R discrimination criteria for differentiating PDfrom HCs Sex and age influenced test scores PD scored below HCs on all measures SPECT imaging found no associations with olfactory measures and dopaminergic degeneration as measured by (1231) β -CITSPECT Indicated data support previous evidence that impaired olfaction in PD is independent of motor signs and disease severity Differing degrees of smell loss found among a range of parkinsonian syndromes, with PD exhibiting the largest deficit Mild impairment in MSA and normal function in PSP and CBD relative to controls UPSIT R score of 25 resulted in sensitivity of 77% and specific of 85% in differentiating PD from atypical parkinsonism Odor perception was compromised in PD and not influenced by medication OERP odor latencies prolonged in both PD groups Trigeminal latencies not impacted by PD or drugs

control

Dotyet al 707

1995 4

Case

180PD 612HCs

UPSIT R

control

Lehrner et al 708

B-threshold Odor ID, Memory SPECT imaging of DAT ligand (1231) β -CIT

1995 4

Case

13PD 13 age-matched HCs

control

Wenning et al 709

1995 4

Case

118PD 29MSA 15PSP 7CBD 123HCs

UPSIT R

control

Barz et al 710

Odor ID,

1997 4

Case

13 medicated PD 18 nonmedicated PD 38 matched HCs

discrimination, OERP

control

(Continues)