xRead - Olfactory Disorders (September 2023)

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435

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point B-SIT Discrimination Threshold

Topic

Study

Year LOE

Conclusions

Tissingh et al 715

PD scored lower on all olfactory tests Negative correlation between the scores on the lengthy odor discrimination test and disease severity PD were less efficient with left nostril in matching task in those with predominant right-sided motor dysfunction diagnosis, 14 at the time or soon after diagnosis, and 14 being unaware of any smell dysfunction Testing found 19 patients with anosmia, 13 with severe hyposmia, and 5 with moderate hyposmia No correlations between test 9 of 37 PD self-reported decreased OF before Abnormal function in 82% of patients compared with 23%ofHCs Only 5 of the 12 test odors needed to meaningfully discriminate PD from controls All measures deficient in PD VPUPSIT R scores better than PD scores and did not differ from HCs, suggesting smell testing can differentiate between PDandVP MeanUPSIT R scoreof those with PARK2 mutations (Parkin disease) did not differ from the HCs Both PD and those without PARK2 mutations had worseOF The authors suggest the possibility that Parkin disease is a distinct separate entity from PD scores and disease severity or duration

2001 4

Case

41PD 18HCs

control

Zucco 716

2001 4

Case

6 early-stage PD 12HCs

Odor naming and matching

control

Muller et al 717

SS-TDI Subjective

2002 4

Case

37PD Normative controls

control

Double et al 718

2003 4

Case

49PD 52HCs

B-SIT

control

Hudryet al 719

2003 4

Case

24PD 24HCs

ID intensity,

control

hedonics familiarity, edibility ratings to 12odors

Katzenschlager et al 720

2004 4

Case

18PD 14VP 27HCs

UPSIT R

control

Khanet al 721

UPSIT R

2004 4

Case

18PD 17 early-onset PDwith PARK2 mutations 11 early-onset PDwithout PARK2 mutations 28HCs

control

(Continues)