xRead - Olfactory Disorders (September 2023)

20426984, 2022, 4, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22929, Wiley Online Library on [04/09/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

436

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Hummel et al 722

SS-T and SS-D No effect of deep brain stimulation on odor threshold to butanol Discrimination

2005 4

Case

11PD (ON/OFF, deep brain stimulation)

control

performance better during “on” period

Ondo and Lai 723

2005 4

Case

20 tremor

UPSIT R

Tremor-dominant PD without family history of tremor had same smell function as nontremor PD; however, tremor-dominant PD with a family history of tremor exhibited better function than the other groups This suggests that the latter At baseline, the twins with PD scored below the twins without PD The latter scored the same asHCs Follow-up on average, 7.3 years Two of 19 available previously unaffected patients converted to PD The change in test scores was greater for these 2 twins than for the 16 twins who did not developPD Age affected smell test scores of all patients over the test-retest period UPSIT R scores correlated with TRODAT uptake in the striatum (r = 0.66) as well as the putamen (r = 0.74) Smell test correlations stronger than UPDRS ratings PD < MSAandHCs Significant correlation in PD between B-SIT scores and cardiac 123I-MIBG uptake Implies that functional losses of the olfactory and may be more akin to patients with essential tremor for whom no smell loss is present

control

dominant PD with family historyof tremor dominant PD withno family history of tremor

15 tremor

25 nontremor PD

Marras et al 724

UPSIT R at baseline B-SITat follow-up

2005 3

Cohort

26 twin pairs

discordant for PD

26HCs

Siderowf et al 725

2005 3

Cross

25 earlyPD

UPSIT R TRODAT SPECT imaging of DAT Symptom ratings

sectional

Lee et al 726

B-SIT

2006 4

Case

26PD 20MSA 15HCs

control

cardiac sympathetic systems are closely coupled in PD

(Continues)