xRead - Olfactory Disorders (September 2023)

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438

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Boesveldt et al 733

2008 4

Case

404PD 150HCs

SS-ID SS-D

65% of PD had impaired ID and 42.1% discrimination relative to HCS Discrimination, but not ID, was correlated with disease duration ID + discrimination did not improve discrimination over ID alone UPSIT R scores than MSA Normal function absent in all PD and in half ofMSA In PD, UPSIT R scores correlated positively with 6-[18F]fluorodopamine derived radioactivity They propose that to clinically differentiate between PD and MSA, olfactory testing should first be performed PD tested 6 and 12 months for smell function after implantation of bilateral electrodes in the substantia nigra Scores were compared preoperatively and postoperatively, as well as with controls and between the medication off/stimulator-on or -off conditions Deep brain stimulation improved recognition thresholds in PD Patients retested over an average period of 4.4 years 4 improved significantly, 4 decreased significantly, and most remained the same Poorer performance in PD No correlations of scores PD had lower mean

control

Goldstein et al 734

2008 4

Case

77PD 57MSA 87HCs

UPSIT R

control

Guoet al 735

15PD 15HCs

Discrimination and ID thresholds

2008 3

Case

control and cohort

Hertig et al 736

2008 3

Cohort

27PD

SS-TDI

Iijima et al 737

2008 4

Case

54PD 50HCs

OSIT-J

control

with motor function, disease duration, or medication

(Continues)