xRead - Olfactory Disorders (September 2023)

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439

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Lötsch 738

2008 4

Case

102PD 2076HCs

SS-TDI

Found olfactory loss occurs in99%of PD Principle component analysis found 1 component with high loadings from ID, threshold, and discrimination tests, and

control

another component loading mainly with threshold

Louis et al 739

2008 3

Cohort

1078

UPSIT R

Healthy persons with some smell loss were 1.55 times

community living persons without PD or dementia

more likely than those without smell loss to

exhibit mild parkinsonian signs—signs believed to be precursors to PD or AD 16% had mild parkinsonian signs Olfaction and neurological state followed for up to 8 years The odds ratio for development of PD in lowest B-SIT quartile was 5.2 compared with the top 2 quartiles This association did not continue beyond 4 years of follow-up Concluded impaired olfaction can predate the diagnosis of clinical PD by at least 4 years and may be useful in detecting persons at high risk forPD confounders, only PD exhibited smell dysfunction, with ET scores being equivalent to HC scores ET with a family history of tremor scored significantly better than HCs and had a slower age-related decline, an effect not seen on OERP After controlling for

Ross et al 132

B-SIT

2008 3

Cohort

2267 men aged 71 to 95 years initially without clinical PD or dementia

Shahet al 740

2008 4

Case

64 tremor

UPSIT R OERP

control

dominant PD

59ET 245HCs

(Continues)