xRead - Olfactory Disorders (September 2023)

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440

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study Silveira

Year LOE

Conclusions

UPSIT R

2008 4

Case

19 parkinsonian and2 asymptomatic carriers of the G2019S mutation 143 sporadic PD 135HCs

MeanUPSIT R scoreof G2019S parkinsonian carriers < HCs and similar to that of sporadic PD 2 asymptomatic mutation carriers had normal UPSIT R scores Postmortem studies of 4 cases found α -synuclein deposition in the olfactory pathways 61% of PD had impaired ID and 43% impaired discrimination No meaningful correlations with demographic or clinical variables Parkin and DJ-1 mutation carriers had normal scores ApoE genotype not related to olfactory scores Olfactory ID score related to higher level of global parkinsonism at baseline and more rapid progression of global parkinsonism on PD performed slightly but significantly worse than HCs on an odor recognition memory task Not present after correction for T scores, suggesting that odor recognition memory is not independently impaired in PD PD scored below HCs on all tests Neither the 32-odor ID nor the 32-odor discrimination test was better at discriminating between PD and HCs than their 16-item counterparts follow-up at 5 years, particularly on gait disturbance

Moriyama et al 741

control

Verbaan et al 742

2008 4

Case

295PD 150HCs

SS-ID SS-D

control

Wilson et al 743

B-SIT

2008 3

Cohort

742 community living older adults

Boesveldt et al 744

2009 4

Case

55PD 50HCs

SS-T Odor recognition memory test

control

Boesveldtl et al 745

2009 4

Case

52PD 50HCs

SS-ID (16 odor) SS-ID (32 odor) SS-D (16 odor) SS-D (32 odor) SS-T

control

(Continues)