xRead - Olfactory Disorders (September 2023)

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441

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions Combining 16-odor ID test with 16-item discrimination test did not improve discrimination, but combining the 16-odor ID test with the threshold test did No other additions aided in this discrimination differentiated PD from HCs, but did not correlate with DAT activity ID impaired in nearly all patients (including PD and PINK1 cases) and preserved in healthy heterozygotes Threshold more preserved and discrimination more impaired in PD with PINK1 mutations than in patients with sporadic PD Alterations of detection and Overall, 97% of PD present with some degree of OD, a value that decreases to 74% when adjusted for age Odor ID was most sensitive to the PD deficit All patients exhibited some degree of measurable orthonasal and retronasal smell dysfunction Olfactory test scores were low and equivalent in PD and RBD but were higher in the sleep apnea group Relative to controls, patients with idiopathic RBD demonstrated substantial olfactory loss Olfaction more impaired in PD than in idiopathic RBD and did not differ between PD with, or without, idiopathic RBD AD-specific subset of UPSIT R items discrimination also observed in PINK1 asymptomatic heterozygotes

Chouet al 746

2009 4

Case

44PD 44HCs

UPSIT R

control

Ferraris et al 747

SS-TDI

2009 4

Case

19 patients with sporadic PD 7PDPINK1 homozygous 6PDPINK1 heterozygous 12 asymptomatic PINK1 heterozygous 67HCs

control

Haehner et al 748

2009 4

Case

400PD Normative controls

SS-TDI

control

Landis et al 749

2009 4

Case

45PD Norms

SS-TDI 10-odor oral powders

control

Miyamoto et al 750

2009 4

Case

21PD 48RBD 34 sleep apnea 33 controls 21 PD without idiopathic RBD 34PDwith idiopathic RBD 68 iiRBD 36HCs

OSIT-J

control

Postuma et al 751

B-SITand

2009 4

Case

UPSIT R

control

(Continues)