xRead - Olfactory Disorders (September 2023)

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INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Shahet al 752

2009 4

Case

75PD 74HCs

UPSIT R

UPSIT R scores lower in PD than inHCs Such scores were not correlated with electrogustometric taste thresholds MeanUPSIT R score higher in HCs that in PAF or MSA; it was lower in PD than in PAF or MSA; no difference between MSA and PAF when adjusted for age, sex, and smoking Hyposmia may be a feature of PAF but to a lesser degree than that found in PD Lower scores in both PD groups than in HCs, with no difference between PD groups Cortical atrophy in olfactory-related brain regions correlated specifically with OD in PD Positive correlations between olfactory performance and gray matter volume were observed in the right piriform cortex in early PD and in the right amygdala in moderately advanced patients UPSIT R scores positively correlated with acetylcholinesterase activity in the hippocampus, amygdala, and neocortex and striatal monoaminergic activity Olfactory test scores correlated positively with

control

Silveira

2009 4

Case

191PD 17PAF 14MSA 145HCs

UPSIT R

Moriyama 753

control

Wattendorf et al 754

SS-ID (12 odors) MRI volume measures

2009 4

Case

15 earlyPD 12 moderate PD 17HCs

control

Bohnen 2010 755

2010 4

Case

58PD 26HCs

UPSIT R Acetyl

control

cholinesterase and monoamine brainPET

scores on cognitive measures of episodic verbal learning

Bovi et al 756

Patients with DIP and poor putamen uptake had abnormal OF, unlike DIP with normal putamen uptake (Continues)

SS-TDI SPECT imaging ofDAT

2010 4

Case

11PD 16DIP 19HCs

control