xRead - Olfactory Disorders (September 2023)

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443

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions Results suggest the smell deficits in DIP may be more related to dopaminergic loss than to a drug-mediated dopamine receptor blockade Apathetic PD performed poorly on the B-SIT compared with nonapathetic PD, and test scores correlated with apathy test scores The simultaneous disruption of olfaction and emotion in PD reflect pathology in brain regions involved in both olfactory and emotional processing The sensitivity of UPSIT R was essentially equivalent to that of DAT SPECT in identifying developing PD UPSIT R correlated moderately with DAT uptake (r = 0.44; P < 0.005) and UPDRS score (r = 0.43; P < 0.05) and weakly with symptom duration (r = 0.25; P < 0.05) OERP showed increased latency but no change in amplitude and no correlation with DAT PD had lower SS-TDI scores than controls Stimuli rated weaker and more pleasant by PD than controls during fMRI scans Both PEA and H2S stimuli were associated with lower activation in the amygdala-hippocampus complex in patients,

Cramer et al 757

2010 4

Case

70PD

B-SIT Apathy

control

Evaluation Scale

MMSE

Deebet al 758

2010 3

Cohort

73 earlyPD

UPSIT R OERP DATSPECT

Hummel et al 759

2010 4

Case

8PD 13HCs

SS-TDI fMRI

control

increased PEA-related activity occurred in the

striatum and the left inferior frontal gyrus In contrast, H2S led to

hypoactivation of the ventral striatum in PD but not HCs and did not enhance left inferior frontal activity

(Continues)