xRead - Olfactory Disorders (September 2023)

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INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Kertelge et al 760

UPSIT R

2010 4

Case

100PD 27 manifesting mutation carriers (15 Parkin, 17 PINK1, 8 LRRK2, 3 SNCA, 4 ATP13A2) 20 nonmanifest ing mutation carriers 110HCs 23 suspected PD 15 possible PD 19 probable PD 37ET 25 patients with restless legs syndrome 33MCI 207HCs

Olfaction was most impaired in PD than in all other groups Within mutation carriers, carriers of 2 mutations in Parkin and PINK1 showed better UPSIT R performance than LRRK2 and SNCA carriers Only probable PD differed significantly from the HCs after controlling for confounds such as age No other groups differed significantly from one another in terms of UPSIT R scores Mean SS-TDI score decreased across a 5-year period, although age was not controlled and a few patients improved On the first test, 3 patients had measurable OERPs; at follow-up, none had OERPs even though most patients were not anosmic PD had lower olfactory test scores than controls The OSIT-J score was related to both cardiac dysfunction, as well as vascular sympathetic dysfunction as indexed by the heart/mediastinum ratio of cardiac MIBG uptake, the fall in orthostatic blood pressure, and heart rate variability Anosmia reported to be present in 96.4% of PD and 49% of HCs PD had larger decrease in systolic blood pressure from a seated to standing position than HCs (Continues) sympathetic and parasympathetic

control

McKinnon et al 761

2010 4

Case

UPSIT R

control

Meusel et al 762

SS-TDI OERP

2010 3

Cohort

19 PD tested twice

separated by a 5-year interval

Oka et al 763

2010 4

Case

66PD 26 olfactory HCs 21 cardiac HCs

OSIT-J 123I-MIBG cardiac

control

scintigraphy

Ramjit et al 764

2010 4

Case

58PD 51 matched HCs

UPSIT R

control