xRead - Olfactory Disorders (September 2023)

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445

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions Heart rate did not differ significantly Reflexive tachycardia was inversely proportional to levodopa equivalent daily dose score (p = .002) Both anosmia and constipation were correlated with disease duration Both PD groups exhibited olfactory deficits, but those with symptoms starting before 45 years of age (early-onset PD) had better sense of smell than late-onset PD prevalent in PD (24%, with 15% severe) than in HCs (6%, with 2% severe) B-SIT scores slightly lower in PD than in HCs (5 vs 6; 20%) The authors conclude that rhinorrhea does not Rhinorrhea is more MeanUPSIT R PSPscores < HCs but > PD In PSP, UPSIT R scores correlated with MMSE but not disease duration, motor subscale of the UPDRS, or the Fullerton Advanced Balance Scale Six progressive supranuclear palsy brains were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in impact B-SIT performance

Santin 765

2010 4

Case

19 early-onset PD 51 late-onset PD 70 matched HCs

SS-ID (12 odors)

control

Sediget al 766

2010 4

Case

61PD 51HCs

B-SIT

control

Silveira

2010 4

Case

140PD 36 progressive

UPSIT R

Moriyama et al 767

control

supranuclear palsy

126HCs

the rhinencephalon, although only 3 had hyposmia

Silveira

SS-ID (16 odors)

The mean SS-ID score in LRRK2 was higher than in noncarrying PD and lower than in controls Patients with low scores

2010 4

Case

14 PD carriers of the heterozygous G2019S LRRK2 mutation. 106PD nonmutation carriers 118 HCs

Moriyama et al 768

control

tended to be younger and to have more dyskinesia, a longer disease course, and a less frequent family history of PD (Continues)