xRead - Olfactory Disorders (September 2023)

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446

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Adenet al 769

2011 4

Case

87PD 28 matched HCs

B-SIT

PD had significantly lower B-SIT scores than controls and had lower intake of polyunsaturated fatty acids and higher intake of carbohydrates In both PD and HCs, lower B-SIT scores were associated with less intake of protein and a low nutrient density of folate, magnesium, and phosphorus Among PD probands, compound heterozygotes hadUPSIT R scores within the normal range and, thus, performed better than heterozygotes and noncarrier PD who had abnormal smell function Among family members without PD, UPSIT R performance was similar in heterozygotes and noncarriers, and better than heterozygotes with PD 96% of PD exhibited some degree of smell loss (40% anosmic, 54% hyposmic) Weak correlations found between UPSIT R score and disease duration, disease severity, and several other measures including BDI, BAI, and daytime sleepiness score of the Scales for Outcomes in Parkinson’s Disease – Sleep questionnaire Those with B-SIT scores < 5 had lower composite memory scores than the other 2 groups The 2 PD groups were

control

Alcalay et al 770

2011 4

Case

PD group: 10 Parkin mutation

UPSIT R

control

heterozygotes, 9 compound heterozygotes, 25 noncarriers members: 18 heterozygotes, 2 compound heterozygotes, 60 noncarriers 96PD Controls: norm data Unaffected family

Berendse et al 771

UPSIT R Multiple

2011 4

Case

control

cognitive and motor measures

Damholdt et al 772

2011 4

Case

24 PD without dementia withB-SIT scores < 5 39PDwith B-SIT scores ≥ 5without dementia 29HCs

B-SIT Cognitive tests

control

indistinguishable on executive function but scored lower than the control group

(Continues)