xRead - Olfactory Disorders (September 2023)

20426984, 2022, 4, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22929, Wiley Online Library on [04/09/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

448

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

UPSIT R LRRK2

Olfaction is impaired in LRRK2 G2019S mutation–related PD, although less overall than PD with no LRRK2 mutation; however, a subset of LRRK2 mutation–carrying family members exhibit some smell dysfunction, suggesting smell loss may The mean OSIT-J score for PD was significantly lower than those for MSA, PSP, and HCs The authors suggest that the OSIT-J test may be useful clinically for both be a marker for PD development in this group UPSIT R score was lower in both LRRK2 and PD than inHCs In LRRK2, a positive correlation was found between myocardial MIBG uptake and UPSIT R scores (r = 0.801, P = 0.001) Since MIBG cardiac reduced uptake and impaired olfaction are markers of Odor recognition thresholds elevated in PD relative to HCs PD associated with reductions in OBVs and olfactory sulcus depths Positive correlations noted between olfactory performance and OBVs in both PD and HCs (Continues) detecting OD in PD and for differential diagnosis LB pathology, these findings may reflect neuropathological heterogeneity among LRRK2

Saunders

2011 4

Case

31LRRK2PD 30 PD with no LRRK2 28 LRRK2 non manifesting family members 46HCs

Pullman et al 779

control

genotyping

Suzuki et al 780

2011 4

Case

98PD 15MSA 7PSP 29HCs

OSIT-J

control

Valldeoriola et al 781

UPSIT R

2011 4

Case

14 idiopathic PD 14LRRK2PD 13HCs

control

Wanget al 782

2011 4

Case

29PD 29HCs

T&T olfactometer MRI brain volume measures

control