xRead - Olfactory Disorders (September 2023)

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PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Siderowf et al 794

26% of patients with ≥ 4 nonmotor features were microsmic, compared with 12% of those having ≤ 3 such features Smell testing may be useful in assessing risk for future neurodegeneration 83.2% PD exhibited smell dysfunction compared with 31.1% of HCs Dysfunction in PD associated with rigidity dominance and disease severity UPSIT R scores significantly lower for PD than HCs No relation of scores to disease stage, duration, or OBVs The proportion of hyposmic individuals was not statistically different in patients with PD-G2019S (50%) and idiopathic PD (82%), but hyposmia was significantly less common in both AsG2019S + (26%) and AsG2019S– (28%) Average score lower in PD than in controls Cutoff of 7 gave 76% sensitivity and 86% specificity for PD diagnosis Test scores significantly lower in PD than in HCs compared with prior baseline UPSIT R demonstrated that both PD and LBD had lower UPSIT R scores than HCs, with PD having the lowest scores UPSIT R scores higher than idiopathic PD scores and hyposmia was less LRRK2-G2019S-PD Postmortem autopsy

2012 4

Case

4350 normals 769 microsmics

UPSIT R Surveyof

control

prodromal PD features

Casjens et al 795

2013 4

Case

148PD 148HCs

SS-ID (16 odor)

control

Hakyemez et al 796

UPSIT R MRIOBVs

2013 4

Case

28 early-stage PD 19HCs

control

Sierra et al 797

2013 4

50 idiopathic PD 50 community controls 49 AsG2019S + 29G2019S associated PD 47non ASG2019S carrier relatives

UPSIT R

Antsov et al 798

2014 4

Case

50PD 50HCs

SS-ID (12 odors)

control

Cecchini et al 799

2014 4

Case

61PD 66HCs 10PD 13LBD 69HCs

SS-ID (16 odors)

control

UPSIT R

Driver-Dunckley et al 800

2014 4

Case

control

Gaiget al 801

2014 4

Case

33 idiopathic PD 33HCs 33LRRK2 G2019S PD

UPSIT R

control

frequent in G2019S carriers than in IPD

(Continues)