xRead - Olfactory Disorders (September 2023)

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452

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions UPSIT R scores higher in female than male LRRK2-PD Hyposmia, depression, sleepiness were reported to occur before the onset of classical motor symptoms in > 40%of LRRK2-PD in whom these symptoms were present at the time of examination differentiated PD and HCs with an 82% sensitivity and 88.2% specificity Hyposmia present at time of diagnosis in sporadic PD; absent in healthy LRRK2 carriers Less pronounced in LRRK2 PD compared with sporadic PD UPSIT R score Moderate agreement between predicted group membership and actual group membership was found for all tests (UPSIT R K = 0.51, SS-16 K = 0.49, B-SIT K = 0.55) Lemon, turpentine, and rose had an ID rate < 25th percentile for all 3 tests Odors with a high ID rate ( > 75th percentile) included banana for all 3 tests, and gasoline, onion constipation and excessive daytime

Picillo et al 802

2014 4

Case

61PD 61HCs

Modified

control

UPSIT R

Johansen et al 803

B-SIT

2014 4

Case

90denovo

control

sporadic PD 17LRRK2PD 36healthy

LRRK2 carriers 15healthy family

members without LRRK2 mutation

Rodriguez Violante et al 804

2014 4

Case

199PD 199HCs

UPSIT R B-SIT SS-ID (16 odors)

control

and chocolate for the UPSIT R andB-SIT

UPSIT R Cardiac MIBG

Navarro-Otano et al 805

2014 4

Case

15PD 15 suspected VP 9HCs

Both PD and VP scored belowHCs VP with a cardiac MIBG nonsuggestive of PD were

control

more likely to have a higher UPSIT R score

(Continues)