xRead - Olfactory Disorders (September 2023)

20426984, 2022, 4, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22929, Wiley Online Library on [04/09/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

453

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Wolz et al 806

SS-TDI

PD had lower TDI scores than ET and other tremor ET and other tremor did not differ from one another TDI and ID scores were related to the absence or presence of PD in tremor patients PD lower than HCs on all SS measures PEA and H2S induced entropy changed among time windows only for HCs The SS-TDI score as well as the ID subdomain had a diagnostic accuracy of predicting conversion to LBD of 82.4% relative risk for LBD in the lowest tertile of OF was 7.3 compared with the top 2 Prevalence rates of hyposmia and substantia nigra hyperechogenicity were 70% and 83.3% in PD, 33.3% and 9.5% in ET, and 17% and 10.6% in HCs Both markers were present in 63% PD, no ET, and in 2 HCs No difference in MRI-determined volumes of OBs between PD and HCs No relationship between test scores and volumes No differences in smell function between PD and major depressive disorder, suggesting depression does not contribute to smell dysfunction of PD

2014 4

Case

167PD 85ET 47 other tremor

control

Guducu et al 807

2015 4

Case

12 unmedicated PD 12HCs

SS-TDI Chemosensory event-related potentials entropy measures

control

Mahlknecht et al 808

2015 3

Cohort

34 patients with RBD

SS-TDI

López Hernández et al 809

2015 4

Case

30PD 21ET 47HCs

SS-ID (12 odor) Transcranial ultrasound hypere chogenicity of substantia nigra

control

Paschen et al 810

2015 4

Case

52PD 31 matched HCs

SS-TDI MRIOBV

control

Rossi et al 811

2015 4

Case

30 PD without major depressive disorder 30PDwith major depressive disorder 29major depressive disorder 30HCs

SS-TDI

control

(Continues)