xRead - Olfactory Disorders (September 2023)

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455

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point SS-ID (12 odor) Cognitive measures Electroen

Topic

Study

Year LOE

Conclusions

Cozac et al 819

In PD, decreases noted in SS-ID, Wisconsin Card Sorting Test, Trail Making Test time for part A, Semantic verbal fluency test, and alpha/theta ratio In PD sample, SS-ID correlated with age, UPDRS-III items related to gait and axial rigidity Electroencephalography global field power found measurable differences between PD and other study groups, indicating different pattern of CNS olfactory processing in PD PD performed significantly worse in olfactory testing than HCs and MSA or PSP No significant difference in test scores between MSA and PSP patients 91.0% exhibited measured smell loss, compared with 55.5% of subjective assessments Subjective hyposmia, dyspepsia, constipation, and bloating differed among groups, being higher in anosmics and hyposmics than normosmics At 2-year follow-up, levodopa challenge with olfactory test scores was more accurate in identifying true PD than without test scores 33 Parkin PD performed better than panel negative patients, but still worse thanHCs The differences persisted after adjusting for confounders OD prevalence in PD was 95.2%; attentional deficits correlated with olfactory loss inPD (Continues) disease duration, UPDRS-III, and

2017 4

Case

54PD 21HCs

control

cephalography

Iannilli et al 820

2017 4

Case

17PD 20 hyposmic non-PD 13anosmic non-PD 21 nonanosmic

SS-TDI (for group classifications)

control

Krismer et al 821

SS-TDI

2017 4

Case

67PD 23MSA 23PSP 41HCs

control

Passali et al 822

2017 4

Case

78PD Normative

SS-TDI Cognitive and motor measures

control

comparisons

Terroba Chambi et al 823

2017 3

Cohort

210PD

SS-TDI Diagnosis

prediction

Wanget al 824

2017 4

Case

33 Parkin PD 49 gene-negative PD 34HCs

SS-ID (12 odors)

control

Camargo et al 825

2018 4

Case

42PD 38HCs

SS-ID (12 odors) Cognitive measures

control