xRead - Olfactory Disorders (September 2023)

20426984, 2022, 4, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22929, Wiley Online Library on [04/09/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

456

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Dolatshahi et al 826

Baseline RBD-Screening Questionnaire scores but not MoCA, UPDRS III, or UPST scores were predictive of longitudinal increase in α -synuclein levels Olfactory scores related to cognitive scores but not serum uric acid levels No significant relationship was found between SS-ID test scores and either the BDI-II or GDS-30 depression measures, although color vision, as measured by the Farnsworth-Munsell 100 Hue Test, was associated with such scores Olfactory scores much lower inPD Both apathy and UPDRS scores correlated with degree of smell loss 68% evidenced hyposmia Correlation of 0.26 found between olfactory test scores and body mass index associated with age, cognition, apathy and visio-spatial dysfunction 79% of PD had impairment vs 7.1%HCs 52% of PD and 6% of HCs overrated their smell ability between PD with and without hyposmia; N1 latency and P1 amplitude related to executive functions in hyposmic group No OERP differences Poor olfaction in PD PD with MCI have greater OD

2018 3

Cohort

112PD 110HCs

UPSIT R RBD-Screening Questionnaire scores CSF α -synuclein t-tau p-tau A β 1-42 Serum uric acid levels Neurocognitive measures SS-ID (12 odor) Depression scales

Lee et al 827

2018 2

Cross

196 de novo PD SS-TDI

sectional

Li et al 828

2018 2

Cross

159PD

sectional

Masala et al 829

2018 4

Case

96PD 51HCs

SS-TDI MoCA Starkstein Apathy Scale PD Fatigue Scale UPDRS

control

Park 830

SS-TDI Cognitive test battery

2018 4

Case

37 cognitively normal PD 29 PD with MCI

control

Roos et al 831

2018 4

Case

63PD Normative data

SS-TDI Body mass index

control

Cecchini et al 832

2019 4

Case

50PD 50HCs

SS-TDI Cognitive test battery

control

Leonhardt et al 833

2019 4

Case

124 PD without dementia 154 elderly HCs

SS-ID (16 odors)

control

Linet al 834

SS-ID (16 odors) OERP MoCA

2019 4

Case

24PDwith hyposmia 19 PD without hyposmia

control

(Continues)