xRead - Olfactory Disorders (September 2023)

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457

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point SS-ID (16 odors)

Topic

Study

Year LOE

Conclusions

Melis et al 835

2019 4

Case

131PD 118HCs

PD scored below HCs OBPIIa gene polymorphism related to olfactory deficits in female PD Those with 2 sensitive alleles (AA) performed better than those with at least 1 insensitive allele (G) SS-ID scores lower in PD than inHCs 90% of PD and 55% of HCs were reportedly anosmic SS-ID scores lower in PD than inHCs Sensitivity and specificity of the German version was 75% and 98%, respectively The corresponding values for the Chinese version were 59% and 97% Reports that deep brain stimulation improves OF although controls were not matched for the same degree of OF and no PD controls provided UPSIT R scores did not differ significantly between the 2 groups; however, based on quantitative anisotropy studies, they appear to have different white matter fiber architecture Thus, the OD in prodromal and early clinical phases of PD may involve distinct pathogenesis Increased network connectivity in prodromal and early PD could be caused by neural compensation PD scores below HC scores PD had most fibers with decreased connectivity in left inferior longitudinal fasciculus, bilateral fornix, bilateral middle cerebellar peduncle, bilateral cingulum, bilateral corticospinal tract and body, genu, and splenium of corpus callosum

control

Pekel 836

2019 4

Case

31PD 31HCs

SS-ID (12 odors) B-threshold

control

Pinkhardt et al 837

SS-ID (12 odors)

2019 4

Case

80PD(39

control

Chinese and 41German) Chinese and 100 German)

170HCs (70

Saatci et al 838

2019 4

Case

45PD 40HCs

SS-TDI

control

Sanjari 839

2019 4

Case

17 prodromal PD 18 earlyPD

UPSIT R Diffusion MRI connectivity measures

control

Sobhani et al 840

2019 4

Case

85 de novo PD 36HCs

UPSIT R Diffusion MRI connectivity

control

(Continues)