xRead - Olfactory Disorders (September 2023)

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536

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VIII.12 (Continued)

Primary end point Correlation of eosinophilic

Study Lavin

Year 2017

LOE Study design Study groups

Conclusions

Controls: 26 patients CRSsNP: 37 patients CRSwNP: 36 patients

4

Observational (cross sectional)

Significant strong

et al 177

negative correlation between ECP and CLC protein in all patients Significant moderate positive correlation between CLC protein and IL-5 and weak positive correlation with CCL11/eotaxin-1 in all patients Significant moderate negative correlation between CLC protein Significant correlations of mucus protein concentration to UPSIT R score CRSsNP Negative correlation: none Positive correlation: IL-7 CRSwNP Negative correlation: IL-5, IL-6, IL-10, IL-13 Positive correlation: none Univariate regression analysis Increased concentrations of IL-2, IL-5, and IL-13 significantly associated with OD Multivariate regression analysis Increased concentration Random forest approach IL-5 and IL-13 with most predictive of OF in CRS Significant correlations of mucus protein concentration to TDI score Negative correlation: CDKN2A/p16INK4a, basic fibroblast growth factor, CCL2, GM-CSF, CCL20 and olfactory threshold and identification in all patients of IL-2 significantly associated with OD

cationic protein withCLC protein correlation with IL-5 and CCL11/eotaxin 1 Correlation with CLC protein SS-T and UPSIT R CLC protein

Wu

2018

4

Observational (cross sectional)

Control: 12 patients CRSsNP: 31 patients CRSwNP: 36 patients

Correlation of

et al 179

olfactory mucus cytokine concentration to UPSIT R

Morse

CRS: 110 patients

Association of

2019

4

Observational (cross sectional)

et al 216

olfactory mucus cytokine concentrations toUPSIT R using cluster analysis and random forest algorithm to examine cytokines most predictive of UPSIT R score

Yoo

2019

4

Observational (cross sectional)

Non-CRS: 34 patients Normosmic: 12 patients Hyposmic/anosmic: 22 patients

Correlation of

et al 1267

olfactory mucus cytokine and select protein concentrations to SS-TDI score

Positive correlation: stem cell factor

(Continues)