xRead - Olfactory Disorders (September 2023)

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387

PATEL et al.

TABLE VII.9 (Continued) Disease Study

Year LOE Study design Study groups

Clinical end point Conclusions

Dahlslett et al 413

2012 4

Case-control

30 patients with MS and 30 controls

Olfactory ERP SS-TDI

Patients with MS

scored worse on TDI Olfactory ERP 23.8% hyposmia TDI 40% hyposmia TDI score inversely correlated with EDSS score Identification inversely correlated with disease duration and EDSS discrimination scores were similar between patients withMSand controls, whereas total TDI and identification values were poorer in patients with MS No correlation between fractional anisotropy reduction in lesions and the EDSS or the TDI score Threshold and correlation with fractional anisotropy values of lesions in the olfactory brain Identification:

Erb

2012 4

Case-control

30 patients with MS and 30 controls

SS-TDI

et al 414

Silva

2012 4

Case-control

153 patients with MS and 165 controls

B-SIT

Patients with MS scored worse on

et al 415

B-SIT compared with controls Age, disease duration,

education, EDSS, depression, and MMSE

Rolet

2013 4

Case series

50 patients with MS SS-TDI

OD was 40% threshold, 18% discrimination, and 10% identification Identification: correlation positivity

et al 416

with EDSS and negatively with medical record TDI was inversely correlated with

disease progression

(Continues)