xRead - Olfactory Disorders (September 2023)

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389

PATEL et al.

TABLE VII.9 (Continued) Disease Study

Year LOE Study design Study groups

Clinical end point Conclusions

Li

2016 4

Case-control

26 patients with MS and 26 controls

T&T olfactometer

42.3% had olfactory impairment but there was no difference between MS and control groups T&T correlated with EDSS OB was smaller in patients with OD scored worse than controls on the UPSIT R ODT correlation with lesion volume 50% hyposmia No significant change during follow-up Discrimination correlated negatively with number of relapses VAS correlated with the TDI score of the longitudinally tested patients Smell identification, smell threshold, and mean olfactory scores were all worse compared with controls Disease duration and and number of MS attacks and CCCRC scores were inversely correlated MOCA test scores and CCCRC scores/subscores were positively correlated Patients with MS

et al 423

Good

2017 4

Case-control

73 patients with MS and 73 controls

UPSIT R ODT

et al 424

Uecker

2017 4

Case series

20 patients with MS SS-TDI

et al 425

Atalar

2018 4

Case-control

31 patients with MS and 24 controls

CCCRC olfactory test

et al 426

Bsteh

SS test (only threshold)

Olfactory threshold was impaired in

2018 4

Case-control

Relapse group: 28

et al 427

patients with MS

patients with acute MS relapse

Stable group: 27

patients with MS as controls

Relapse group MS EDSS < controls

Ciurleo

2018 4

Case series

30RRMS

CCCRC olfactory test

MS olfactory alterations were related to disability progression and disease activity (Continues)

et al 428