xRead - Olfactory Disorders (September 2023)

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407

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions AD had less activation in right piriform and anterior ventral temporal cortex but not in the left piriform area Right piriform activation correlated with UPSIT R scores cingulate gyrus more likely to be anosmic than HCs (41% vs 6%) Non-LB AD not more likely to be anosmic than HCs CAMCOG no worse in anosmics than in nonanosmics Study limited by questionable olfactory test Intensity scores were lower in older controls and AD familiarity and ID scores were lower in AD patients than in older controls and younger control No differences between groups for pleasantness and edibility judgements AD performed more poorly on both olfactory tests, identifying fewer odors and having higher AST threshold than age- and education-matched HCs AD scores were lower than VDorMD Test discriminated with 95% Rasch scaling determined that decline of UPSIT R in AD equivalent to that experienced by HCs over the course of 30 years UPSIT R reliability was high (KR-20 = 0.93) Patients with LB in patients than in the younger controls and classification accuracy (100% sensitivity; 92.5% specificity)

McShane 579

2001 4

Case

92AD 94HCs

Perception of 1

control

concentration of lavender water measures of LB and other AD pathology

Postmortem

Royet et al 580

Odor ID, ratings of intensity, hedonics familiarity, edibility

2001 4

Case

15AD 15 older HCs 15 younger HCs

control

Chanet al 581

2002 4

Case

12AD 12HCs

SDOIT AST

control

Duff et al 582

PST

2002 4

Case

20AD 20VD 20MD

control

Lange et al 583

2002 4

Case

48AD 15PD 41mixed

UPSIT R

control

diagnoses

73HCs

(Continues)