xRead - Olfactory Disorders (September 2023)

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408

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point UPSIT R B-threshold SDOIT

Topic

Study

Year LOE

Conclusions

Tests differentiated between ADandHCs Combining sensory and OERP P3 latency produced 100% correct classification B-SIT scores lower in MCI than inHCs The scores correlated positively with CAMCOG-Chinese version, but not with age, sex, or years of education ApoE ε 4 allele frequency was higher in MCI than inHCs MCI allele carriers identified fewer odors AD exhibited poorer ID and threshold performance Strong correlation (r = 0.85) between SDOIT and left hippocampal volume in AD Strong correlations in HCs between olfactory measures and mesial temporal lobe volumes AST thresholds elevated relative to HCs TDI score indicated 12 of AD and 7 of MCI were hyposmic All HCs were normosmic OERP absent in 4 of MCI and in 7 of AD OERP present in a number of hyposmic AD and MCI Both AD and LBD exhibited dysfunction, although performance was lower in

Morganand Murphy 584

2002 4

Case

12AD 12HCs OERP

control

Wanget al 585

2002 4

Case

28MCI 30 age-matched HCs

B-SIT

control

Murphy et al 586

12AD 22HCs

SDOIT B-threshold

2003 4

Case

control and MRI imaging correla tions

Getchell et al 587

2003 4

Case

18AD 6HCs 14AD 8MCI 8HCs

AST

control

Peters et al 588

SS-TDI OERP

2003 4

Case

control

Westervelt et al 589

2003 4

Case

9AD 9LBD

B-SIT

control

LBD than in AD (64% correct in AD and 32% correct in LBD)

Gilbert et al 590

OM B-threshold

LBD performed worse than AD AD performed worse than HCs

2004 4

Case

12AD 12LBD 12HCs

control

(Continues)