xRead - Olfactory Disorders (September 2023)

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409

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point B-threshold RMT

Topic

Study

Year LOE

Conclusions

Gilbert et al 591

AD performed more poorly on threshold task Hit rate on memory test was same among groups, but false-positive rate was elevated for the AD as well as ApoE ε 4 + without dementia AD compromised on both olfactory tests Picture test discriminated better between the 2 groups Within AD, higher correlations between Picture-based ID test scores and MMSE scores were present for ApoE ε 4 allele carriers than noncarriers aMCI showed impairment in smell function relative to controls AD had lower odor ID scores than either the MCI or the 2 HC groups, which did not differ from one another For all tests, AD scores < MCI < HCs 10 items from UPSIT R found to be optimal in making these differentiations Scores were low in AD compared with VD and HCs, which did not differ from one another distinguished the 2 groups with high sensitivity and specificity AD-associated memory impairment was not related to the test scores Olfactory testing

2004 4

Case

38

control

pathologically confirmed AD

38 probable AD 38 elderly HCs

Suzuki et al 592

2004 4

Case

85AD 30HCs

B-SIT Picture-based ID test

control

Eibenstein et al 593

2005 4

Case

29aMCI 20HCs

SS-ID (16 odors)

control

Sparks et al 594

2005 4

9AD 21MCI 16 high-function HCs 24 high-function HCs

UPSIT R

Retrospective, case control

Tabert et al 595

UPSIT R B-SIT 10-item ID test

2005 4

Case

100AD 147MCI 63HCs

control

Motomura and Tomota 596

2006 4

Case

12AD 12VD 30HCs

B-SIT

control

Kjelvik et al 597

2007 4

Case

39AD 52HCs

B-SIT

control

(Continues)